Browsing by Author "Ndege, Caroline"
Now showing items 1-4 of 4
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Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia
Raballah, Evans; Anyona, Samuel B; Cheng, Qiuying; Munde, Elly O; Hurwitz, Ivy-Foo; Onyango, Clinton; Ndege, Caroline; Hengartner, Nicolas W; Pacheco, Maria Andreína; Escalante, Ananias A; Lambert, Christophe G; Ouma, Collins; Obama, Henri C Jr T; Schneider, Kristan A; Seidenberg, Philip D; McMahon, Benjamin H; Perkins, Douglas J (Experimental Biology and Medicine, 2021-11-19)Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ... -
Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
Anyona, Samuel B.; Raballah, Evans; Cheng, Qiuying; Hurwitz, Ivy; Ndege, Caroline; Munde, Elly; Otieno, Walter; Seidenberg, Philip D.; Schneider, Kristan A.; Lambert, Christophe G.; McMahon, Benjamin H.; Ouma, Collins; Perkins, Douglas J. (Frontiers in Genetics, 2021-11-22)Background: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin ...