Browsing by Author "Perkins, Douglas J."
Now showing items 1-16 of 16
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Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya
Munde, Elly O.; Okeyo, Winnie A.; Raballah, Evans; Anyona, Samuel B.; Were, Tom; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases, 2017-04-20)Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized ... -
CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia Abstract
Raballah, Evans; Kempaiah, Prakasha; Karim, Zachary; Orinda, George O.; Otieno, Michael F.; Perkins, Douglas J.; Ong’echa, John Michael (Plos one, 2017-04-20)In Plasmodium falciparum holoendemic transmission regions of western Kenya, life-threatening pediatric malaria manifests primarily as severe malarial anemia (SMA, Hb≤6.0 g/dL with any density parasitemia). To determine the ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya
Kubicek-Sutherland, Jessica Z.; Xie, Gary; Shakya, Migun; Dighe, Priya K.; Jacobs, Lindsey L.; Daligault, Hajnalka; Davenport, Karen; Stromberg, Loreen R.; Stromberg, Zachary R.; Cheng, Qiuying; Kempaiah, Prakasha; Ong’echa, John Michael; Otieno, Vincent; Raballah, Evans; Anyona, Samuel; Ouma, Collins; Chain, Patrick S. G.; Perkins, Douglas J.; Mukundan, Harshini; McMahon, Benjamin H.; Doggett, Norman A. (PLOS ONE, 2021-01-01)Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to ... -
Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
Anyona, Samuel B.; Raballah, Evans; Cheng, Qiuying; Hurwitz, Ivy; Ndege, Caroline; Munde, Elly; Otieno, Walter; Seidenberg, Philip D.; Schneider, Kristan A.; Lambert, Christophe G.; McMahon, Benjamin H.; Ouma, Collins; Perkins, Douglas J. (Frontiers in Genetics, 2021-11-22)Background: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin ... -
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
Kubicek-Sutherland, Jessica Z.; Vu, Dung M.; Aneesa, Noormohamed; Mendez, Heather M.; Stromberg, Loreen R.; Pedersen, Christine A.; Hengartner, Astrid C.; Klosterman, Katja E.; Haley, A. Bridgewater; Otieno, Vincent; Cheng, Qiuying; Anyona, Samuel B.; Ouma, Collins; Raballah, Evans; Perkins, Douglas J.; McMahon, Benjamin H.; Mukundan, Harshini (Scientific Reports, 2019-04-17)Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ... -
Draft Genome Sequences of Two Staphylococcus warneri Clinical Isolates, Strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), from Siaya County Referral Hospital, Siaya, Kenya.
Xie, Gary; Cheng, Qiuying; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Kubicek-Sutherland, Jessica; LeCuyer, Tessa; Otieno, Vincent; Raballah, Evans; Doggett, Norman; Mukundan, Harshini; Perkins, Douglas J.; McMahon, Benjamin (ASM Journals, 2019-04-11)We report the complete draft genome sequences of two Staphylococcus warneri clinical isolates, strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), each of which contains one chromosome and at least one plasmid. Isolate ... -
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya
Kisia, Lily E.; Cheng, Qiuying; Raballah, Evans; Munde, Elly O.; McMahon, Benjamin H.; Hengartner, Nick W.; Ong’echa, John M.; Chelimo, Kiprotich; Lambert, Christophe G.; Ouma, Collins; Kempaiah, Prakasha; Perkins, Douglas J.; Schneider, Kristan A.; Anyona, Samuel B. (Tropical Medicine and Health, 2022-06-25)Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ... -
Genome Sequence of a Staphylococcus xylosus Clinical Isolate, Strain SMA0341-04 (UGA5), from Siaya County Referral Hospital in Siaya, Kenya
Cheng, Qiuying; Xie, Gary; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Kubicek-Sutherland, Jessica; LeCuyer, Tessa; Otieno, Vincent; Raballah, Evans; Doggett, Norman; McMahon, Benjamin; Perkins, Douglas J.; Mukundan, Harshini (ASM Journals, 2019-04-18)We report here the genome sequence of a Staphylococcus xylosus clinical isolate, strain SMA0341-04 (UGA5), which contains one chromosome and at least one plasmid. Notably, strain SMA0341-04 (UGA5) contains the tetracycline ... -
Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
Munde, Elly O.; Raballah, Evans; Okeyo, Winnie A.; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases volume, 2017-04-20)Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility ... -
Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya
Olewe, Perez K.; Awandu, Shehu Shagari; Munde, Elly O.; Anyona, Samuel B.; Raballah, Evans; Amolo, Asito S.; Ogola, Sidney; Ndenga, Erick; Onyango, Clinton O.; Rochford, Rosemary; Perkins, Douglas J.; Ouma, Collins (BMC Cancer, 2023-06-20)Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. ... -
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
Olewe, Perez K.; Cheng, Qiuying; Munde, Elly O.; Raballah, Evans; Anyona, Samuel B.; McMahon, Benjamin H.; Lambert, Christophe G.; Onyango, Patrick O.; Schneider, Kristan A.; Perkins, Douglas J.; Ouma, Collins (Springer Link, 2023-09-13)Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common ... -
Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia
Olewe, Perez K.; Awandu, Shehu Shagari; Munde, Elly O.; Anyona, Samuel B.; Raballah, Evans; Amolo, Asito S.; Ogola, Sidney; Ndenga, Erick; Onyango, Clinton O.; Rochford, Rosemary; Perkins, Douglas J.; Ouma, Collins (BMC Cancer, 2023-06-20)Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. ... -
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
Anyona, Samuel B.; Cheng, Qiuying; Raballah, Evans; Hurwitz, Ivy; Lambert, Christophe G.; McMahon, Benjamin H.; Ouma, Collins; Perkins, Douglas J. (Biochemistry and Biophysics Reports, 2022-01-11)Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ... -
Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children
Raballah, Evans; Wilding, Kristen; Anyona, Samuel B.; Munde, Elly O.; Hurwitz, Ivy; Onyango, Clinton O.; Ayieko, Cyrus; Lambert, Christophe G.; Schneider, Kristan A.; Seidenberg, Philip D.; Ouma, Collins; McMahon, Benjamin H.; Cheng, Qiuying; Perkins, Douglas J. (Frontier in genetics, 2022-08-14)Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated ...