Browsing Gold Collection by Subject "Ranscriptomic, Proteomic, Insights, Host Immune, Responses, Pediatric, Severe, Malarial, Anemia, Dysregulation, HSP60-70-TLR2/4 Signaling, Altered, Glutamine, Metabolism"

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Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism

Onyango, Clinton O; Anyona, Samuel B; Hurwitz, Ivy; Evans, Raballah; Wasena, Sharely A; Osata, Shamim W; Seidenberg, Philip; McMahon, Benjamin H; Lambert, Christophe G; Schneider, Kristan A; Ouma, Collins; Cheng, Qiuying; Perkins, Douglas J (Pathogens, 2024-09-03)

Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission zones. This study explored the entire expressed human transcriptome in ...