Browsing by Author "Obakiro, Samuel Baker"
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Deciphering the antimycobacterial, cytotoxicity and phytochemical profile of Entada abyssinica stem bark
Obakiro, Samuel Baker; Omara, Timothy; Kiprop, Ambrose; Bunalema, Lydia; Kowino, Isaac; Kigondu, Elizabeth (An International Journal of Plant Research and Biotechnology, 2023-09-07)Organic (acetonic, chloroform, methanolic and hexanic) extracts of Entada abyssinica stem bark were screened for their antimycobacterial, cytotoxicity and phytochemical profiles. Microplate Alamar Blue and MTT assays were ... -
Ethnobotany, ethnopharmacology, and phytochemistry of traditional medicinal plants used in the management of symptoms of tuberculosis in East Africa: a systematic review
Obakiro, Samuel Baker; Kiprop, Ambrose; Kowino, Isaac; Kigondu, Elizabeth; Odero, Mark Peter; Omara, Timothy; Bunalema, Lydia (Tropical Medicine and Health, 2022-08-14)Objective Many studies on the treatment of tuberculosis (TB) using herbal medicines have been undertaken in recent decades in East Africa. The details, however, are highly fragmented. The purpose of this study was to ... -
Molecular Docking Interactions with Mycobacterial ATP and Polyketide-13 Synthase Enzymes of Phytoconstituents Isolated from Entada abyssinica Stem Bark
Obakiro, Samuel Baker; K'Owino, Isaac; Kigondu, Elizabeth; Andima, Moses; Owor, Richard Oriko; Kiprop, Ambrose (Biointerface Research in Applied Chemistry, 2022-11-09)The search for novel therapies for tuberculosis continues due to the emergence of resistant strains, adverse drug reactions, and potential drug-drug interactions of antitubercular drugs. This study was undertaken to ... -
Phytochemical, Cytotoxicity, and Antimycobacterial Activity Evaluation of Extracts and Compounds from the Stem Bark of Albizia coriaria Welw ex. Oliver
Obakiro, Samuel Baker; Kiprop, Ambrose; K’owino, Isaac; Andima, Moses; Owor, Richard Oriko; Chacha, Robi; Kigondu, Elizabeth (Evidence-Based Complementary and Alternative Medicine, 2022-01-22)ackground. Albizia coriaria Welw ex. Oliver (Fabaceae) is one of the plants used by herbalists in the East Africa community to prepare herbal remedies for the management of symptoms of TB. Despite its widespread use, the ... -
Sub-Acute Toxicity Effects of Methanolic Stem Bark Extract of Entada abyssinica on Biochemical, Haematological and Histopathological Parameters in Wistar Albino Rats
Obakiro, Samuel Baker; Kiprop, Ambrose; Kigondu, Elizabeth; K’owino, Isaac; Kiyimba, Kenedy; Kato, Charles Drago; Gavamukulya, Yahaya (Frontiers in Pharmacology, 2021-09-07)Background: Whereas the efficacy of Entada abyssinica (fabaceae) extracts against various ailments has been scientifically validated, its safety has not been established. This study was undertaken to evaluate the toxicity ... -
Traditional Medicinal Uses, Phytoconstituents, Bioactivities, and Toxicities of Erythrina abyssinica Lam. ex DC. (Fabaceae): A Systematic Review
Obakiro, Samuel Baker; Kiprop, Ambrose; Kigondu, Elizabeth; K’Owino, Isaac; Odero, Mark Peter; Manyim, Scolastica; Omara, Timothy; Namukobe, Jane; Owor, Richard Oriko; Gavamukulya, Yahaya; Bunalema, Lydia (Evidence-Based Complementary and Alternative Medicine, 2021-03-04)Background. Many studies have been undertaken on the medicinal values of Erythrina abyssinica Lam. ex DC. (Fabaceae). The details, however, are highly fragmented in different journals, libraries, and other publication ...