Browsing by Author "Okoth, Patrick"
Now showing items 1-20 of 35
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Comparative genomic analysis of gene clusters of Pseudomonas aeruginosa that define specific biofilm formation in deciphering target regions for novel treatment options
Ambutsi, Michael; Okoth, Patrick (Scientific African, 2021-09) -
Contraindications of Batch Staining in Malaria Diagnosis and its implications on Drug and Vaccine Protective Efficacy
Osoga, Joseph; Obare, Peter; Odera, James Sande; Ogutu, Bernhard’s; Nanakorn, Ampon; Okoth, Patrick; Ohrt, Colin (Elixir International Journal, 2013-05-13)The primary objective was to evaluate if batch staining of malaria blood films results in false positive smears. False positive smears (>1%) may cause a serious underestimate of a drug’s or vaccine’s protective efficacy, ... -
Distribution of hemoglobinopathy phenotypes in western Kenya: a retrospective study done at Aga Khan Hospital, Kisumu
Mutua, Benard; Sowayi, George; Okoth, Patrick (The Egyptian Journal of Internal Medicine, 2022-06-07)Background Hemoglobinopathies are inheritable disorders of hemoglobin and are the most common genetic defects in humans. This is a neglected public health problem whose undiagnosis remain a major threat to its prevention ... -
Ebola Virus Disease, Diagnostics and Therapeutics: Where is the Consensus in Over Three Decades of Clinical Research?
Kebenei, Collins Kipkorir; Okoth, Patrick (Scientific African, 2021-07-22)Ebola virus is a neglected tropical disease widely accepted as one of the most fatal diseases of human and nonhuman primates ever encountered in recent years. For a long time, development of vaccines and anti-Ebola drugs ... -
Ebola Virus Disease, Diagnostics and Therapeutics: Where is the Consensus in Over Three Decades of Clinical Research?
Kebenei, Collins Kipkorir; Okoth, Patrick (Scientific African, 2021-09-13)Ebola virus is a neglected tropical disease widely accepted as one of the most fatal diseases of human and nonhuman primates ever encountered in recent years. For a long time, development of vaccines and anti-Ebola drugs ... -
Expression of Physiologic Biomolecules following Anti-Malarial Cytokine Cytokine-CpG Motif Oligodeoxynucleotide Gene Therapy
Okoth, Patrick (MMUST, 2015) -
High-performance liquid chromatography local reference ranges of hemoglobin fractions (HbA, HbA2, and HbF) in detection of hemoglobinopathies in western Kenya
Mutua, Benard; Chelangat, Rose; Mustafa, Barasa; Were, Tom; Makani, Julie; Sowayi, George; Okoth, Patrick (The Egyptian Journal of Internal Medicine, 2022-12-29)Background Western Kenya, being a malaria-endemic region, has a high prevalence of hemoglobinopathies mostly sickle cell and thalassemia. The hemoglobin fractions or variants, HbA, HbA2, and HbF, serve as biomarkers for ... -
Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa
Wambani, Josephine; Okoth, Patrick (Journal of Tropical Medicine, 2022-03-22)Worldwide, transmission of emerging and reemerging malaria infections poses a significant threat to human health in the Sub-Saharan Africa, one that can quickly overwhelm public health resources. While the disease burden ... -
In Silico Identification of New Anti-SARS-CoV-2 Main Protease (Mpro) Molecules with Pharmacokinetic Properties from Natural Sources Using Molecular Dynamics (MD) Simulations and Hierarchical Virtual Screening
Onyango, Harrison; Odhiambo, Patrick; Angwenyi, David; Okoth, Patrick (HINDAWI, 2022-10-10)Infectious agents such as SARS-CoV, MERS-CoV, and SARS-CoV-2 have emerged in recent years causing epidemics with high mortality rates. The quick development of novel therapeutic compounds is required in the fight against ... -
In-silico analysis of potent Mosquirix vaccine adjuvant leads
Onyango, Okello Harrison; Mwenda, Cynthia Mugo; Gitau, Grace; Muoma, John; Okoth, Patrick (Journal of Genetic Engineering and Biotechnology, 2023-11-30)Background World Health Organization recommend the use of malaria vaccine, Mosquirix, as a malaria prevention strategy. However, Mosquirix has failed to reduce the global burden of malaria because of its inefficacy. The ... -
Modeling the Spatial Impact of Climate Change on Grevy’s Zebra (Equus grevyi) niche in Kenya
Kigen, C.; Okoth, Patrick; Konje, Martha; Shivoga, W.; Ochieno, Dennis; Wanjala, S.; Agevi, H.; Onyando, Z.; Soy, B.; Kisoyan, P.; Makind, S. (Environmental Science, 2013-09-02)Although Grevy’s zebra (Equus grevyi) is listed as endangered species and is an important attraction in Kenya’s tourism industry, there have been no attempts to model the implications of climate change on their niche. This ... -
Molecular Characterization of Indigenous Rhizobia from Kenyan Soils Nodulating with Common Beans
Wekesa, Clabe; Kiprotic, Kelvin; Okoth, Patrick; Asudi, George O.; Muoma, John O.; Furch, Alexandra C. U.; Oelmüller, Ralf (International Journal of Molecular Sciences, 2023-05-30): Kenya is the seventh most prominent producer of common beans globally and the second leading producer in East Africa. However, the annual national productivity is low due to insufficient quantities of vital nutrients ... -
Molecular Diversity of a Seemingly Altitude Restricted Ustilago kamerunensis Isolates in Kenya: A Pathogen of Napier Grass
Omayio, Dennis O.; Musyimi, David M.; Muyekho, Francis N.; Ajanga, Samuel I.; Midega, Charles A. O.; Wekesa, Clabe S.; Okoth, Patrick; Kariuki, Innocent W. (American Journal of Molecular Biology, 2022-04-27)The Central region of Kenya which is the second largest market oriented dairy zone, faces a threat in milk production. The challenge is a disease known as the napier head smut caused by Ustilago kamerunensis. This fungal ... -
Molecular Modelling of Insecticide Binding Sites of the Voltage-Gated Sodium Channels of Fall Armyworm, (Spodoptera frugiperda)
Gichere, Savinda Njeri; Khamala, Alfred Alinda; Ambutsi, Michael; Khakame, Kakai Shem; Okoth, Patrick (Egyptian Academic Journal of Biological Sciences(A. Entomology), 2021-08-05)Fall armyworm is a polyphagous migratory pest. Insecticides are used as major components of integrated pest management to control the pest, however, full dependence on insecticides has made the pest evolve resistance to ... -
Monkeypox: genetic, clinical, molecular, diagnostic, and therapeutic perspectives
Wambani, Josephine; Were, Tom; Okoth, Patrick (Journal of Rare Diseases, 2024-06-17)Monkeypox is a DNA virus that belongs to the orthopox virus family with two distinct clades known as West African and Congo Basin. This virus was initially discovered in crab-eating Macaques in 1958 and in 1970s it spread ... -
Mutational signatures for breast cancer diagnosis using artificial intelligence
Odhiambo, Patrick; Okello, Harrison; Wakaanya, Annette; Wekesa, Clabe; Okoth, Patrick (Journal of the Egyptian National Cancer Institute, 2023-05-15)Background Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures are ... -
Mutational signatures for breast cancer diagnosis using artificial intelligence
Odhiambo, Patrick; Okello, Harrison; Wakaanya, Annette; Wekesa, Clabe; Okoth, Patrick (Journal of the Egyptian National Cancer Institute, 2023-05-15)Background Breast cancer is the most common female cancer worldwide. Its diagnosis and prognosis remain scanty, imprecise, and poorly documented. Previous studies have indicated that some genetic mutational signatures are ... -
Pangenomics of the cichlid species (Oreochromis niloticus) reveals genetic admixture ancestry with potential for aquaculture improvement in Kenya
Mwaura, John G.; Wekesa, Clabe; Kelvin, Kiprotich; Paul, Ang’ienda; Ogutu, Philip A.; Okoth, Patrick (The Journal of Basic and Applied Zoology, 2023-10-08)Background Nile tilapia has a variety of phenotypes suitable for aquaculture farming, yet its entire gene pool with potential for breeding climate ready strains in resource-limited settings remains scanty and poorly ... -
The Potential of DNA Barcode-Based Delineation Using Seven Putative Candidate Loci of the Plastid Region in Inferring Molecular Diversity of Cowpea at Sub-Species Level.
Okoth, Patrick; Muoma, John; Emmanuel, Mulaya; Clabe, Wekesa; Omayio, Dennis O; Angienda, Paul O (American Journal of Molecular Biology, 2016-10)The novelty and suitability of the mitochondrial gene CO1 in DNA barcoding as a reliable identification tool in animal species are undisputed. This is attributed to its standardized sequencing segment of the mitochondrial ... -
Prognostic Potential of RDW in Discriminating Hemoglobinopathies among Patients reporting to Aga Khan Hospital, Kisumu
Mutua, Benard; Sowayi, George; Okoth, Patrick (Egyptian Journal of Medical Human Genetics, 2022-08-13)Background Red cell distribution width (RDW) measures the extent of variation in red blood cell (RBC) volume in terms of coefficient of variation. It reflects the degree of variation in RBC’s sizes and shapes, characteristic ...