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    Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation 

    Kempaiah, Prakasha; Dokladny, Karol; Karim, Zachary; Raballah, Evans; Ong’echa, John M; Moseley, Pope L; Perkins, Douglas J (Molecular Medicine, 2016-08-30)
    Severe malarial anemia (SMA; hemoglobin [Hb] <5.0 g/dL) is a leading global cause of morbidity and mortality among children residing in Plasmodium falciparum transmission regions. Exploration of molecular pathways through ...
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    Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

    Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BMC Immunology, 2013-03-25)
    In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
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    Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia 

    Raballah, Evans; Anyona, Samuel B; Cheng, Qiuying; Munde, Elly O; Hurwitz, Ivy-Foo; Onyango, Clinton; Ndege, Caroline; Hengartner, Nicolas W; Pacheco, Maria Andreína; Escalante, Ananias A; Lambert, Christophe G; Ouma, Collins; Obama, Henri C Jr T; Schneider, Kristan A; Seidenberg, Philip D; McMahon, Benjamin H; Perkins, Douglas J (Experimental Biology and Medicine, 2021-11-19)
    Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ...
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    Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum 

    Kisia, Lily E.; Kempaiah, Prakasha; Anyona, Samuel B.; Munde, Elly O.; Achieng, Angela O.; Ong’echa, John M.; Lambert, Christophe G.; Chelimo, Kiprotich; Ouma, Collins; Perkins, Douglas J; Raballah, Evans (BMC Med Genet., 2019-08-16)
    Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic ...
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    Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region. 

    Anyona, Samuel B; Hengartner, Nicolas W; Raballah, Evans; Ong'echa, John Michael; Lauve, Nick; Cheng, Qiuying; Fenimore, Paul W; Ouma, Collins; Lambert, Christophe G; McMahon, Benjamin H; Perkins, Douglas J (Journal of Human Genetics, 2019-10-29)
    Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the ...
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    Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

    Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BMC Imunology, 2013-03-25)
    n holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe malaria ...
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    Genome Sequences of a Staphylococcus aureus Clinical Isolate, Strain SMA0034-04 (UGA22), from Siaya County Referral Hospital in Siaya, Kenya 

    Xie, Gary; Cheng, Qiuying; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Sutherland, Jessica Kubicek; LeCuyer, Tessa; Otieno, Vincent; Raballah, Evans; Mukundan, Harshini; Perkins, Douglas J; McMahon, Benjamin; Doggett, Norman (ASM Journals, 2019-04-25)
    Here, we report the genome sequences of a Staphylococcus aureus clinical isolate, strain SMA0034-04 (UGA22), which contains one chromosome and one plasmid. We also reveal that isolate SMA0034-04 (UGA22) contains loci in ...
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    Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels. 

    Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BMC Immunology, 2013-03-13)
    In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
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    Genome Sequence of Staphylococcus pettenkoferi Strain SMA0010-04 (UGA20), a Clinical Isolate from Siaya County Referral Hospital in Siaya, Kenya 

    Otieno, Vincent; Xie, Gary; Cheng, Qiuying; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Kubicek-Sutherland, Jessica; LeCuyer, Tessa; Raballah, Evans; Doggett, Norman; Mukundan, Harshini; McMahon, Benjamin; Perkins, Douglas J (Microbiology Resource Announcements, 2019-04-25)
    Here, we report the sequence of a Staphylococcus pettenkoferi clinical isolate, strain SMA0010-04 (UGA20), which contains the PC1 beta-lactamase (blaZ) gene.

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    Perkins, Douglas J (9)
    Raballah, Evans (9)
    Ouma, Collins (6)Anyona, Samuel B (5)Cheng, Qiuying (4)Munde, Elly O (4)Ong’echa, John M (4)Okeyo, Winnie A (3)Okumu, Wilson (3)Vulule, John M (3)... View MoreSubjectComplement, component, 3 mutations ,alter, longitudinal, risk, pediatric, malaria, severe, malarial, anemia (1)Cyclooxygenase-2, haplotypes, longitudinal, risk , malaria ,severe ,malarial, anemia, Kenyan, children, holoendemic ,transmission, region (1)Genetic, variation, interleukin-7, associated , reduced, erythropoietic, response, Kenyan, children, infected, Plasmodium, falciparum (1)Genome, Sequence ,Staphylococcus, pettenkoferi, Strain, SMA0010-04 (UGA20), Clinical, Isolate (1)Genome, Sequences , Staphylococcus, aureus, Clinical, Isolate, Strain SMA0034-04 (UGA22), (1)Interleukin (IL)-13, promoter polymorphisms, (-7402 T/G,-4729G/A) ,condition, susceptibility , pediatric, severe, malarial ,anemia , circulating ,IL-13 levels. (1)Interleukin (IL)-13, promoter, polymorphisms, (-7402 T/G ,4729G/A) ,condition, susceptibility, pediatric, severe, malarial, anemia,circulating, IL-13, levels (1)Interleukin (IL)-13, promoter, polymorphisms, (-7402 T/G and -4729G/A) ,condition, susceptibility, pediatric ,severe, malarial, anemia , circulating IL-13 levels. (1)Reduced, Hsp70 , Glutamine, Pediatric, Severe, Malaria, Anemia,Role of hemozoin, Suppressing, Hsp70 , NF-κB, Activation (1)... View MoreDate Issued2019 (4)2013 (3)2016 (1)2021 (1)Has File(s)
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