Show simple item record

dc.contributor.authorKimutai, Nicholas K.
dc.contributor.authorOgutu, Philip A.
dc.contributor.authorMutai, Charles
dc.date.accessioned2021-12-31T06:41:37Z
dc.date.available2021-12-31T06:41:37Z
dc.date.issued2021-05
dc.identifier.urihttps://doi.org/10.3923/ajps.2021.470.476
dc.identifier.urihttps://scialert.net/abstract/?doi=ajps.2021.470.476
dc.identifier.urihttp://ir-library.mmust.ac.ke:8080/xmlui/handle/123456789/1916
dc.description.abstractBackground and Objective: Traditional healers have long used plants to treat bacterial infections caused by resistant bacteria. Hence, there is an increased interest in the ethnopharmacological approach to identify new novel compounds from plants to treat these infections. The objective of this study, therefore, was to test successive extracts and their fractions. Materials and Methods: The roots of Leucas calostachys were obtained, dried and ground. The total methanol extract was obtained and screen for antibacterial activities. Successive extracts were extracted using four different solvents hexane, dichloromethane, ethyl acetate and methanol. The bioactive solvent extracts were fractionated. Successive extracts and fractions were then screened for antibacterial activities against ten pathogenic bacteria in vitro using the disk diffusion method. Results: The results indicated the solvent extracts and fractions were active against both gram-negative and gram-positive bacteria with the lowest MIC value of 3.15 mg mL–1 obtained from total methanol extract against methicillin-resistant Staphylococcus aureus. Conclusion: This demonstrated that hexane extracts and fractions could be helpful in the management of resistant bacterial infections. This work is the first attempt to fractionate and test fractions of L. calostachys, which can be used for the development of phytomedicine.en_US
dc.language.isoenen_US
dc.publisherScience alerten_US
dc.subjectAntibacterial, Activities, Investigation, Leucas, calostachys, Root, Extractsen_US
dc.titleAntibacterial Activities Investigation of Leaucas calostachys Root Extracs  Asian Journal of Plant Sciences en_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record