Browsing by Author "Hurwitz, Ivy"
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Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia
Anyona, Samuel B.; Raballah, Evans; Cheng, Qiuying; Hurwitz, Ivy; Ndege, Caroline; Munde, Elly; Otieno, Walter; Seidenberg, Philip D.; Schneider, Kristan A.; Lambert, Christophe G.; McMahon, Benjamin H.; Ouma, Collins; Perkins, Douglas J. (Frontiers in Genetics, 2021-11-22)Background: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin ... -
Entire Expressed Peripheral Blood Transcriptome in Pediatric Severe Malarial Anemia
Anyona, Samuel; Cheng, Qiuying; Guo, Yan; Raballah, Evans; Hurwitz, Ivy; Onyango, Clinton; Seidenberg, Philip; Schneider, Kristan; Lambert, Christophe; McMahon, Benjamin; Ouma, Collins; Perkins, Douglas (Research Square, 2023-06-19)This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, analyzed the entire expressed transcriptome in whole blood from children with non-SMA (Hb ≥ 6.0 g/dL, ... -
Ingestion of hemozoin by peripheral blood mononuclear cells alters temporal gene expression of ubiquitination processes
Anyona, Samuel B.; Cheng, Qiuying; Raballah, Evans; Hurwitz, Ivy; Lambert, Christophe G.; McMahon, Benjamin H.; Ouma, Collins; Perkins, Douglas J. (Biochemistry and Biophysics Reports, 2022-01-11)Plasmodium falciparum (Pf) malaria is among the leading causes of childhood morbidity and mortality worldwide. During a natural infection, ingestion of the malarial parasite product, hemozoin (PfHz), by circulating phagocytic ... -
Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children
Raballah, Evans; Wilding, Kristen; Anyona, Samuel B.; Munde, Elly O.; Hurwitz, Ivy; Onyango, Clinton O.; Ayieko, Cyrus; Lambert, Christophe G.; Schneider, Kristan A.; Seidenberg, Philip D.; Ouma, Collins; McMahon, Benjamin H.; Cheng, Qiuying; Perkins, Douglas J. (Frontier in genetics, 2022-08-14)Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated ...