Browsing by Author "Onyango, Clinton"
Now showing items 1-4 of 4
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Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia
Raballah, Evans; Anyona, Samuel B; Cheng, Qiuying; Munde, Elly O; Hurwitz, Ivy-Foo; Onyango, Clinton; Ndege, Caroline; Hengartner, Nicolas W; Pacheco, Maria Andreína; Escalante, Ananias A; Lambert, Christophe G; Ouma, Collins; Obama, Henri C Jr T; Schneider, Kristan A; Seidenberg, Philip D; McMahon, Benjamin H; Perkins, Douglas J (Experimental Biology and Medicine, 2021-11-19)Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ... -
Entire Expressed Peripheral Blood Transcriptome in Pediatric Severe Malarial Anemia
Anyona, Samuel; Cheng, Qiuying; Guo, Yan; Raballah, Evans; Hurwitz, Ivy; Onyango, Clinton; Seidenberg, Philip; Schneider, Kristan; Lambert, Christophe; McMahon, Benjamin; Ouma, Collins; Perkins, Douglas (Research Square, 2023-06-19)This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, analyzed the entire expressed transcriptome in whole blood from children with non-SMA (Hb ≥ 6.0 g/dL, ...