Browsing by Author "Seidenberg, Philip"

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Entire Expressed Peripheral Blood Transcriptome in Pediatric Severe Malarial Anemia

Anyona, Samuel; Cheng, Qiuying; Guo, Yan; Raballah, Evans; Hurwitz, Ivy; Onyango, Clinton; Seidenberg, Philip; Schneider, Kristan; Lambert, Christophe; McMahon, Benjamin; Ouma, Collins; Perkins, Douglas (Research Square, 2023-06-19)

This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, analyzed the entire expressed transcriptome in whole blood from children with non-SMA (Hb ≥ 6.0 g/dL, ...
Transcriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism

Onyango, Clinton O; Anyona, Samuel B; Hurwitz, Ivy; Evans, Raballah; Wasena, Sharely A; Osata, Shamim W; Seidenberg, Philip; McMahon, Benjamin H; Lambert, Christophe G; Schneider, Kristan A; Ouma, Collins; Cheng, Qiuying; Perkins, Douglas J (Pathogens, 2024-09-03)

Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission zones. This study explored the entire expressed human transcriptome in ...