dc.contributor.author | Shaviya, Nathan | |
dc.contributor.author | Budambula, Valentine | |
dc.contributor.author | Webale, Mark K | |
dc.contributor.author | Were, Tom | |
dc.date.accessioned | 2021-06-03T14:04:35Z | |
dc.date.available | 2021-06-03T14:04:35Z | |
dc.date.issued | 2016-01-05 | |
dc.identifier.uri | https://doi.org/10.1155/2016/9415364 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/26880909/ | |
dc.identifier.uri | http://r-library.mmust.ac.ke/123456789/1584 | |
dc.description.abstract | Although interferon-gamma, interleukin-10, and adiponectin are key immunopathogenesis mediators of tuberculosis, their association with clinical manifestations of early stage disease is inconclusive. We determined interferon-gamma, interleukin-10, and adiponectin levels in clinically and phenotypically well-characterised non-substance using new pulmonary tuberculosis patients (n = 13) and controls (n = 14) from Kenya. Interferon-gamma levels (P < 0.0001) and interferon-gamma to interleukin-10 (P < 0.001) and interferon-gamma to adiponectin (P = 0.027) ratios were elevated in tuberculosis cases. Correlation analyses in tuberculosis cases showed associations of interferon-gamma levels with body weight (ρ = -0.849; P < 0.0001), body mass index (ρ = 0.664; P = 0.013), hip girth (ρ = -0.579; P = 0.038), and plateletcrit (ρ = 0.605; P = 0.028); interferon-gamma to interleukin-10 ratio with diastolic pressure (ρ = -0.729; P = 0.005); and interferon-gamma to adiponectin ratio with body weight (ρ = -0.560; P = 0.047), body mass index (ρ = -0.604; P = 0.029), and plateletcrit (ρ = 0.793; P = 0.001). Taken together, our results suggest mild-inflammation in early stage infection characterised by upregulation of circulating interferon-gamma production in newly infected TB patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | National Library of Medicine | en_US |
dc.subject | Interferon-Gamma Levels, Low Body Weight, Diagnosed, Non-Substance, Tuberculosis | en_US |
dc.title | Circulating Interferon-Gamma Levels Are Associated with Low Body Weight in Newly Diagnosed Kenyan Non-Substance Using Tuberculosis Individuals | en_US |
dc.type | Article | en_US |