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Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children

Raballah, Evans; Wilding, Kristen; Anyona, Samuel B.; Munde, Elly O.; Hurwitz, Ivy; Onyango, Clinton O.; Ayieko, Cyrus; Lambert, Christophe G.; Schneider, Kristan A.; Seidenberg, Philip D.; Ouma, Collins; McMahon, Benjamin H.; Cheng, Qiuying; Perkins, Douglas J. (Frontier in genetics, 2022-08-14)

Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated ...

Entire Expressed Peripheral Blood Transcriptome in Pediatric Severe Malarial Anemia

Anyona, Samuel; Cheng, Qiuying; Guo, Yan; Raballah, Evans; Hurwitz, Ivy; Onyango, Clinton; Seidenberg, Philip; Schneider, Kristan; Lambert, Christophe; McMahon, Benjamin; Ouma, Collins; Perkins, Douglas (Research Square, 2023-06-19)

This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, analyzed the entire expressed transcriptome in whole blood from children with non-SMA (Hb ≥ 6.0 g/dL, ...

Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia

Raballah, Evans; Anyona, Samuel B; Cheng, Qiuying; Munde, Elly O; Hurwitz, Ivy-Foo; Onyango, Clinton; Ndege, Caroline; Hengartner, Nicolas W; Pacheco, Maria Andreína; Escalante, Ananias A; Lambert, Christophe G; Ouma, Collins; Obama, Henri C Jr T; Schneider, Kristan A; Seidenberg, Philip D; McMahon, Benjamin H; Perkins, Douglas J (Experimental Biology and Medicine, 2021-11-19)

Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ...

Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide

Kubicek-Sutherland, Jessica Z.; Vu, Dung M.; Aneesa, Noormohamed; Mendez, Heather M.; Stromberg, Loreen R.; Pedersen, Christine A.; Hengartner, Astrid C.; Klosterman, Katja E.; Haley, A. Bridgewater; Otieno, Vincent; Cheng, Qiuying; Anyona, Samuel B.; Ouma, Collins; Raballah, Evans; Perkins, Douglas J.; McMahon, Benjamin H.; Mukundan, Harshini (Scientific Reports, 2019-04-17)

Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ...

Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia

Olewe, Perez K.; Cheng, Qiuying; Munde, Elly O.; Raballah, Evans; Anyona, Samuel B.; McMahon, Benjamin H.; Lambert, Christophe G.; Onyango, Patrick O.; Schneider, Kristan A.; Perkins, Douglas J.; Ouma, Collins (Springer Link, 2023-09-13)

Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common ...

Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region.

Anyona, Samuel B; Hengartner, Nicolas W; Raballah, Evans; Ong'echa, John Michael; Lauve, Nick; Cheng, Qiuying; Fenimore, Paul W; Ouma, Collins; Lambert, Christophe G; McMahon, Benjamin H; Perkins, Douglas J (Journal of Human Genetics, 2019-10-29)

Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the ...

Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya

Kubicek-Sutherland, Jessica Z.; Xie, Gary; Shakya, Migun; Dighe, Priya K.; Jacobs, Lindsey L.; Daligault, Hajnalka; Davenport, Karen; Stromberg, Loreen R.; Stromberg, Zachary R.; Cheng, Qiuying; Kempaiah, Prakasha; Ong’echa, John Michael; Otieno, Vincent; Raballah, Evans; Anyona, Samuel; Ouma, Collins; Chain, Patrick S. G.; Perkins, Douglas J.; Mukundan, Harshini; McMahon, Benjamin H.; Doggett, Norman A. (PLOS ONE, 2021-01-01)

Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to ...

Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H

Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)

Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ...

Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children

Achieng, Angela O.; Hengartner, Nicolas W.; Raballah, Evans; Cheng, Qiuying; Anyona, Samuel B.; Lauve, Nick; Guyah, Bernard; Foo-Hurwitz, Ivy; Ong'echa, John M.; McMahon, Benjamin H.; Ouma, Collins; Lambert, Christophe G.; Perkinsa, Douglas J. (EBioMedicine, 2019-07-02)

Background Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ...

Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya

Kisia, Lily E.; Cheng, Qiuying; Raballah, Evans; Munde, Elly O.; McMahon, Benjamin H.; Hengartner, Nick W.; Ong’echa, John M.; Chelimo, Kiprotich; Lambert, Christophe G.; Ouma, Collins; Kempaiah, Prakasha; Perkins, Douglas J.; Schneider, Kristan A.; Anyona, Samuel B. (Tropical Medicine and Health, 2022-06-25)

Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte ...