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    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya 

    Munde, Elly O.; Okeyo, Winnie A.; Raballah, Evans; Anyona, Samuel B.; Were, Tom; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases, 2017-04-20)
    Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized ...
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    Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H 

    Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)
    Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ...
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    Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum 

    Kisia, Lily E.; Kempaiah, Prakasha; Anyona, Samuel B.; Munde, Elly O.; Achieng, Angela O.; Ong’echa, John M.; Lambert, Christophe G.; Chelimo, Kiprotich; Ouma, Collins; Perkins, Douglas J; Raballah, Evans (BMC Med Genet., 2019-08-16)
    Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic ...
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    Factors associated with non-adherence to Artemisinin-based combination therapy (ACT) to malaria in a rural population from holoendemic region of western Kenya 

    Onyango, Elizabeth O; Ayodo, George; Watsierah, Carren A; Were, Tom; Okumu, Wilson; Anyona, Samuel B; Raballah, Evans; Okoth, John M; Gumo, Sussy; Orinda, George O; Ouma, Collins (National Library of Medicine, 2012-06-24)
    Background: Over the years, reports implicate improper anti-malarial use as a major contributor of morbidity and mortality amongst millions of residents in malaria endemic areas, Kenya included. However, there are limited ...
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    Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels 

    Munde, Elly O.; Okeyo, Winnie A.; Anyona, Samwel B.; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (ASM Journals, 2012-11-12)
    An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) ...
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    Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya 

    Kubicek-Sutherland, Jessica Z.; Xie, Gary; Shakya, Migun; Dighe, Priya K.; Jacobs, Lindsey L.; Daligault, Hajnalka; Davenport, Karen; Stromberg, Loreen R.; Stromberg, Zachary R.; Cheng, Qiuying; Kempaiah, Prakasha; Ong’echa, John Michael; Otieno, Vincent; Raballah, Evans; Anyona, Samuel; Ouma, Collins; Chain, Patrick S. G.; Perkins, Douglas J.; Mukundan, Harshini; McMahon, Benjamin H.; Doggett, Norman A. (PLOS ONE, 2021-01-01)
    Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to ...
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    Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide 

    Kubicek-Sutherland, Jessica Z.; Vu, Dung M.; Aneesa, Noormohamed; Mendez, Heather M.; Stromberg, Loreen R.; Pedersen, Christine A.; Hengartner, Astrid C.; Klosterman, Katja E.; Haley, A. Bridgewater; Otieno, Vincent; Cheng, Qiuying; Anyona, Samuel B.; Ouma, Collins; Raballah, Evans; Perkins, Douglas J.; McMahon, Benjamin H.; Mukundan, Harshini (Scientific Reports, 2019-04-17)
    Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ...
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    Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya 

    Were, Tom; Wesongah, Jesca O; Munde, Elly; Ouma, Collins; Kahiga, Titus M; Owuor, Francisca Ongecha; Kiarie, James N; Ahmed, Aabid A; Makokha, Ernest P; Budambula, Valentine (BMC Clin Pathol, 2014-07-09)
    Background: Although the co-burden of injection drug use and HIV is increasing in Africa, little is known about the laboratory markers of injection drug use and anti-retroviral treatment (ART) in Kenyan injection drug ...
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    Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya 

    Munde, Elly O.; Raballah, Evans; Okeyo, Winnie A.; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases volume, 2017-04-20)
    Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility ...
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    Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region. 

    Anyona, Samuel B; Hengartner, Nicolas W; Raballah, Evans; Ong'echa, John Michael; Lauve, Nick; Cheng, Qiuying; Fenimore, Paul W; Ouma, Collins; Lambert, Christophe G; McMahon, Benjamin H; Perkins, Douglas J (Journal of Human Genetics, 2019-10-29)
    Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the ...
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    Ouma, Collins (20)
    Raballah, Evans (18)Anyona, Samuel B. (7)Cheng, Qiuying (7)Okumu, Wilson (7)Perkins, Douglas J. (7)Anyona, Samuel B (6)Munde, Elly O. (6)Were, Tom (6)McMahon, Benjamin H. (5)... View MoreSubjectChanges , frequencies, Plasmodium, falciparum, dhps , dhfr drug-resistant, mutations, children ,Western, Kenya from 2005 to 2018: the rise of Pfdhps S436H (1)Clinical, chemistry, profiles, injection, heroin users (1)Comparative, genomic , phenotypic, characterization ,invasive, non-typhoidal ,Salmonella, isolates (1)Cyclooxygenase-2, haplotypes, longitudinal, risk , malaria ,severe ,malarial, anemia, Kenyan, children, holoendemic ,transmission, region (1)Diagnostic, accuracy, Th1 (IFN-γ, TNF-α, and IL-2) Th2 (IL-4, IL-6 ,IL-10) cytokines, response , AFB, microscopy, smear, negative, PTB- HIV co-infected, patients (1)Direct, detection, bacteremia, exploiting, host-pathogen, interactions, lipoteichoic, acid, lipopolysaccharide (1)Erratum to: Hepatitis B virus, sero-profiles, genotypes, HIV-1 infected, uninfected, injection,Non-injection, drug,users (1)Fcγ receptor IIA, IIIA ,IIIB, genetic, polymorphisms severe malaria, anemia, children (1)Genetic, variation, interleukin-7, associated , reduced, erythropoietic, response, Kenyan, children, infected, Plasmodium, falciparum (1)Haplotype , non-synonymous, mutations, IL-23R , associated, susceptibility,severe, malaria, anemia , P. falciparum, holoendemic, transmission (1)... View MoreDate Issued2019 (5)2012 (4)2013 (2)2017 (2)2022 (2)2014 (1)2015 (1)2018 (1)2020 (1)2021 (1)Has File(s)
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