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    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya 

    Munde, Elly O.; Okeyo, Winnie A.; Raballah, Evans; Anyona, Samuel B.; Were, Tom; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases, 2017-04-20)
    Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized ...
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    Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children 

    Raballah, Evans; Wilding, Kristen; Anyona, Samuel B.; Munde, Elly O.; Hurwitz, Ivy; Onyango, Clinton O.; Ayieko, Cyrus; Lambert, Christophe G.; Schneider, Kristan A.; Seidenberg, Philip D.; Ouma, Collins; McMahon, Benjamin H.; Cheng, Qiuying; Perkins, Douglas J. (Frontier in genetics, 2022-08-14)
    Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated ...
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    Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya 

    Olewe, Perez K.; Awandu, Shehu Shagari; Munde, Elly O.; Anyona, Samuel B.; Raballah, Evans; Amolo, Asito S.; Ogola, Sidney; Ndenga, Erick; Onyango, Clinton O.; Rochford, Rosemary; Perkins, Douglas J.; Ouma, Collins (BMC Cancer, 2023-06-20)
    Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. ...
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    Genome Sequence of a Staphylococcus xylosus Clinical Isolate, Strain SMA0341-04 (UGA5), from Siaya County Referral Hospital in Siaya, Kenya 

    Cheng, Qiuying; Xie, Gary; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Kubicek-Sutherland, Jessica; LeCuyer, Tessa; Otieno, Vincent; Raballah, Evans; Doggett, Norman; McMahon, Benjamin; Perkins, Douglas J.; Mukundan, Harshini (ASM Journals, 2019-04-18)
    We report here the genome sequence of a Staphylococcus xylosus clinical isolate, strain SMA0341-04 (UGA5), which contains one chromosome and at least one plasmid. Notably, strain SMA0341-04 (UGA5) contains the tetracycline ...
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    Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide 

    Kubicek-Sutherland, Jessica Z.; Vu, Dung M.; Aneesa, Noormohamed; Mendez, Heather M.; Stromberg, Loreen R.; Pedersen, Christine A.; Hengartner, Astrid C.; Klosterman, Katja E.; Haley, A. Bridgewater; Otieno, Vincent; Cheng, Qiuying; Anyona, Samuel B.; Ouma, Collins; Raballah, Evans; Perkins, Douglas J.; McMahon, Benjamin H.; Mukundan, Harshini (Scientific Reports, 2019-04-17)
    Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ...
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    Human NCR3 gene variants rs2736191 and rs11575837 alter longitudinal risk for development of pediatric malaria episodes and severe malarial anemia 

    Olewe, Perez K.; Cheng, Qiuying; Munde, Elly O.; Raballah, Evans; Anyona, Samuel B.; McMahon, Benjamin H.; Lambert, Christophe G.; Onyango, Patrick O.; Schneider, Kristan A.; Perkins, Douglas J.; Ouma, Collins (Springer Link, 2023-09-13)
    Background Plasmodium falciparum malaria is a leading cause of pediatric morbidity and mortality in holoendemic transmission areas. Severe malarial anemia [SMA, hemoglobin (Hb) < 5.0 g/dL in children] is the most common ...
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    Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya 

    Kubicek-Sutherland, Jessica Z.; Xie, Gary; Shakya, Migun; Dighe, Priya K.; Jacobs, Lindsey L.; Daligault, Hajnalka; Davenport, Karen; Stromberg, Loreen R.; Stromberg, Zachary R.; Cheng, Qiuying; Kempaiah, Prakasha; Ong’echa, John Michael; Otieno, Vincent; Raballah, Evans; Anyona, Samuel; Ouma, Collins; Chain, Patrick S. G.; Perkins, Douglas J.; Mukundan, Harshini; McMahon, Benjamin H.; Doggett, Norman A. (PLOS ONE, 2021-01-01)
    Non-typhoidal Salmonella (NTS) is a major global health concern that often causes bloodstream infections in areas of the world affected by malnutrition and comorbidities such as HIV and malaria. Developing a strategy to ...
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    Draft Genome Sequences of Two Staphylococcus warneri Clinical Isolates, Strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), from Siaya County Referral Hospital, Siaya, Kenya. 

    Xie, Gary; Cheng, Qiuying; Daligault, Hajnalka; Davenport, Karen; Gleasner, Cheryl; Jacobs, Lindsey; Kubicek-Sutherland, Jessica; LeCuyer, Tessa; Otieno, Vincent; Raballah, Evans; Doggett, Norman; Mukundan, Harshini; Perkins, Douglas J.; McMahon, Benjamin (ASM Journals, 2019-04-11)
    We report the complete draft genome sequences of two Staphylococcus warneri clinical isolates, strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), each of which contains one chromosome and at least one plasmid. Isolate ...
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    Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H 

    Pacheco, M. Andreína; Schneider, Kristan A.; Cheng, Qiuying; Munde, Elly O.; Ndege, Caroline; Onyango, Clinton; Raballah, Evans; Anyona, Samuel B.; Ouma, Collins; Perkins, Douglas J.; Escalante, Ananias A. (Malaria Journal, 2020-10-22)
    Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ...
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    Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya 

    Munde, Elly O.; Raballah, Evans; Okeyo, Winnie A.; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases volume, 2017-04-20)
    Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility ...
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    Perkins, Douglas J. (16)
    Raballah, Evans (16)Ouma, Collins (13)Anyona, Samuel B. (11)Cheng, Qiuying (11)Munde, Elly O. (9)McMahon, Benjamin H. (7)Schneider, Kristan A. (6)Lambert, Christophe G. (5)Mukundan, Harshini (4)... View MoreSubjectCD4 T-cell, expression , IFN-γ, IL-17, pediatric, malarial, anemia (1)Changes , frequencies, Plasmodium, falciparum, dhps , dhfr drug-resistant, mutations, children ,Western, Kenya from 2005 to 2018: the rise of Pfdhps S436H (1)Changes,frequencies,Plasmodium, falciparum, dhps, dhfr, drug-resistant, mutations, children, Western 2005, 2018, rise, Pfdhps S436H (1)Comparative, genomic , phenotypic, characterization ,invasive, non-typhoidal ,Salmonella, isolates (1)Differential, Gene, Expression, Host, Ubiquitination, Processes, Childhood, Malarial, Anemia (1)Direct, detection, bacteremia, exploiting, host-pathogen, interactions, lipoteichoic, acid, lipopolysaccharide (1)Draft, Genome, Sequences , Two Staphylococcus warneri ,Clinical, Isolates, Strains SMA0023-04 (UGA3) , SMA0670-05 (UGA28), (1)Fcγ receptor IIA, IIIA ,IIIB, genetic, polymorphisms severe malaria, anemia, children (1)Genetic variation, CSF2 (5q31.1), associated, longitudinal, susceptibility, pediatric, malaria, severe malaria,l anemia, cause mortality, high-burden, malaria, HIV, region (1)Genome, Sequence ,Staphylococcus, xylosus ,Clinical, Isolate, Strain SMA0341-04 (UGA5), (1)... View MoreDate Issued2017 (3)2019 (3)2022 (3)2023 (3)2020 (2)2021 (2)Has File(s)Yes (16)

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