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    Association between Fcγ receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya 

    Munde, Elly O.; Okeyo, Winnie A.; Raballah, Evans; Anyona, Samuel B.; Were, Tom; Ong’echa, John M.; Perkins, Douglas J.; Ouma, Collins (BMC Infectious Diseases, 2017-04-20)
    Background Naturally-acquired immunity to Plasmodium falciparum malaria develops after several episodes of infection. Fc gamma receptors (FcγRs) bind to immunoglobulin G (IgG) antibodies and mediate phagocytosis of opsonized ...
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    Polymorphisms in the Fc Gamma Receptor IIIA and Toll-Like Receptor 9 Are Associated with Protection against Severe Malarial Anemia and Changes in Circulating Gamma Interferon Levels 

    Munde, Elly O.; Okeyo, Winnie A.; Anyona, Samwel B.; Raballah, Evans; Konah, Stephen; Okumu, Wilson; Ogonda, Lilian; Vulule, John; Ouma, Collins (ASM Journals, 2012-11-12)
    An understanding of the immunogenetic basis of naturally acquired immunity to Plasmodium falciparum infection would aid in the designing of a rationally based malaria vaccine. Variants within the Fc gamma receptors (FcγRs) ...
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    Nonsynonymous amino acid changes in the α-chain of complement component 5 influence longitudinal susceptibility to Plasmodium falciparum infections and severe malarial anemia in kenyan children 

    Raballah, Evans; Wilding, Kristen; Anyona, Samuel B.; Munde, Elly O.; Hurwitz, Ivy; Onyango, Clinton O.; Ayieko, Cyrus; Lambert, Christophe G.; Schneider, Kristan A.; Seidenberg, Philip D.; Ouma, Collins; McMahon, Benjamin H.; Cheng, Qiuying; Perkins, Douglas J. (Frontier in genetics, 2022-08-14)
    Background: Severe malarial anemia (SMA; Hb < 5.0 g/dl) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions such as western Kenya. Methods: We investigated ...
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    Entire Expressed Peripheral Blood Transcriptome in Pediatric Severe Malarial Anemia 

    Anyona, Samuel; Cheng, Qiuying; Guo, Yan; Raballah, Evans; Hurwitz, Ivy; Onyango, Clinton; Seidenberg, Philip; Schneider, Kristan; Lambert, Christophe; McMahon, Benjamin; Ouma, Collins; Perkins, Douglas (Research Square, 2023-06-19)
    This study on severe malarial anemia (SMA: Hb < 6.0 g/dL), a leading global cause of childhood morbidity and mortality, analyzed the entire expressed transcriptome in whole blood from children with non-SMA (Hb ≥ 6.0 g/dL, ...
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    HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users 

    Budambula, Valentine; Musumba, Francis O.; Webale, Mark K.; Kahiga, Titus M.; Owuor, Francisca Ongecha; Kiarie, James N.; Sowayi, George A.; Ahmed, Aabid A.; Ouma, Collins; Were, Tom (AIDS Research and Therapy, 2015-08-15)
    Background Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations ...
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    Interleukin (IL)-13 promoter polymorphisms (-7402 T/G and -4729G/A) condition susceptibility to pediatric severe malarial anemia but not circulating IL-13 levels 

    Okeyo, Winnie A; Munde, Elly O; Okumu, Wilson; Raballah, Evans; Anyona, Samuel B; Vulule, John M; Ong’echa, John M; Perkins, Douglas J; Ouma, Collins (BMC Immunology, 2013-03-25)
    In holoendemic Plasmodium falciparum transmission areas such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dL, with any density parasitemia] is the most common clinical manifestation of severe ...
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    HIV-1 protease inhibitor drug resistance in Kenyan antiretroviral treatment-naive and -experienced injection drug users and non-drug users 

    Budambula, Valentine; Musumba, Francis O.; Webale, Mark K.; Kahiga, Titus M.; Owuor, Francisca Ongecha; Kiarie, James N.; Sowayi, George A.; Ahmed, Aabid A.; Ouma, Collins; Were, Tom (AIDS Research and Therapy, 2015-08-15)
    Background Although injection drug use drives antiretroviral drug resistance, the prevalence of protease inhibitor (PI) resistance among Kenyan IDUs remains undetermined. We, therefore, explored PI resistance mutations ...
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    Clinical chemistry profiles in injection heroin users from Coastal Region, Kenya 

    Were, Tom; Wesongah, Jesca O; Munde, Elly; Ouma, Collins; Kahiga, Titus M; Owuor, Francisca Ongecha; Kiarie, James N; Ahmed, Aabid A; Makokha, Ernest P; Budambula, Valentine (BMC Clin Pathol, 2014-07-09)
    Background: Although the co-burden of injection drug use and HIV is increasing in Africa, little is known about the laboratory markers of injection drug use and anti-retroviral treatment (ART) in Kenyan injection drug ...
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    Hemoglobinopathies, merozoite surface protein-2 gene polymorphisms, and acquisition of Epstein Barr virus among infants in Western Kenya 

    Olewe, Perez K.; Awandu, Shehu Shagari; Munde, Elly O.; Anyona, Samuel B.; Raballah, Evans; Amolo, Asito S.; Ogola, Sidney; Ndenga, Erick; Onyango, Clinton O.; Rochford, Rosemary; Perkins, Douglas J.; Ouma, Collins (BMC Cancer, 2023-06-20)
    Background Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. ...
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    Complement component 3 mutations alter the longitudinal risk of pediatric malaria and severe malarial anemia 

    Raballah, Evans; Anyona, Samuel B; Cheng, Qiuying; Munde, Elly O; Hurwitz, Ivy-Foo; Onyango, Clinton; Ndege, Caroline; Hengartner, Nicolas W; Pacheco, Maria Andreína; Escalante, Ananias A; Lambert, Christophe G; Ouma, Collins; Obama, Henri C Jr T; Schneider, Kristan A; Seidenberg, Philip D; McMahon, Benjamin H; Perkins, Douglas J (Experimental Biology and Medicine, 2021-11-19)
    Severe malarial anemia (SMA) is a leading cause of childhood morbidity and mortality in holoendemic Plasmodium falciparum transmission regions. To gain enhanced understanding of predisposing factors for SMA, we explored ...
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    Ouma, Collins (34)
    Raballah, Evans (27)Cheng, Qiuying (14)Anyona, Samuel B. (13)Perkins, Douglas J. (13)Munde, Elly O. (11)Anyona, Samuel B (9)McMahon, Benjamin H. (8)Okumu, Wilson (8)Were, Tom (8)... View MoreSubjectAssessing, application, adapted theory, planned behavior, predicting, postpartum, family planning, intentions, pragmatic randomized, control trial, (1)Changes , frequencies, Plasmodium, falciparum, dhps , dhfr drug-resistant, mutations, children ,Western, Kenya from 2005 to 2018: the rise of Pfdhps S436H (1)Changes,frequencies,Plasmodium, falciparum, dhps, dhfr, drug-resistant, mutations, children, Western 2005, 2018, rise, Pfdhps S436H (1)Clinical, chemistry, profiles, injection, heroin users (1)Comparative, genomic , phenotypic, characterization ,invasive, non-typhoidal ,Salmonella, isolates (1)Complement, component, 3 mutations ,alter, longitudinal, risk, pediatric, malaria, severe, malarial, anemia (1)Cyclooxygenase-2, haplotypes, longitudinal, risk , malaria ,severe ,malarial, anemia, Kenyan, children, holoendemic ,transmission, region (1)Diagnostic, accuracy, Th1 (IFN-γ, TNF-α, and IL-2) Th2 (IL-4, IL-6 ,IL-10) cytokines, response , AFB, microscopy, smear, negative, PTB- HIV co-infected, patients (1)Differential, Gene, Expression, Host, Ubiquitination, Processes, Childhood, Malarial, Anemia (1)Direct, detection, bacteremia, exploiting, host-pathogen, interactions, lipoteichoic, acid, lipopolysaccharide (1)... View MoreDate Issued2020 - 2025 (15)2012 - 2019 (19)Has File(s)Yes (34)

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