MMUST Institutional Repository: Recent submissions
Now showing items 1681-1700 of 2256
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Haplotype of non-synonymous mutations within IL-23R is associated with susceptibility to severe malaria anemia in a P. falciparum holoendemic transmission area of Kenya
(BMC Infectious Diseases volume, 2017-04-20)Background Improved understanding of the molecular mechanisms involved in pediatric severe malarial anemia (SMA) pathogenesis is a crucial step in the design of novel therapeutics. Identification of host genetic susceptibility ... -
The role of mycobacterium tuberculosis antigen specific cytokines in determination of acid fast bacilli culture status in pulmonary tuberculosis patients co-infected with human immunodeficiency virus
(The Pan African Medical Journal, 2018-11-08)Introduction: the interaction between Mycobacterium tuberculosis and HIV leads to rapid progression of tuberculosis (TB) and human immunodeficiency virus (HIV)-induced immunosuppression. Diagnosis of TB in these patients ... -
The diagnostic accuracy of Th1 (IFN-γ, TNF-α, and IL-2) and Th2 (IL-4, IL-6 and IL-10) cytokines response in AFB microscopy smear negative PTB- HIV co-infected patients
(Microbiology Resource Announcements, 2019-04)Acid Fast Bacilli (AFB) microscopy smear remains the most widely used laboratory diagnostic technique for Pulmonary Tuberculosis (PTB) in low-and-middle income countries. Although it is highly specific, the sensitivity ... -
Draft Genome Sequences of Two Staphylococcus warneri Clinical Isolates, Strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), from Siaya County Referral Hospital, Siaya, Kenya.
(ASM Journals, 2019-04-11)We report the complete draft genome sequences of two Staphylococcus warneri clinical isolates, strains SMA0023-04 (UGA3) and SMA0670-05 (UGA28), each of which contains one chromosome and at least one plasmid. Isolate ... -
Direct detection of bacteremia by exploiting host-pathogen interactions of lipoteichoic acid and lipopolysaccharide
(Scientific Reports, 2019-04-17)Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. The early diagnosis of bacteremia and initiation of treatment saves lives, especially in high-disease ... -
Genome Sequence of a Staphylococcus xylosus Clinical Isolate, Strain SMA0341-04 (UGA5), from Siaya County Referral Hospital in Siaya, Kenya
(ASM Journals, 2019-04-18)We report here the genome sequence of a Staphylococcus xylosus clinical isolate, strain SMA0341-04 (UGA5), which contains one chromosome and at least one plasmid. Notably, strain SMA0341-04 (UGA5) contains the tetracycline ... -
Genome Sequence of Staphylococcus pettenkoferi Strain SMA0010-04 (UGA20), a Clinical Isolate from Siaya County Referral Hospital in Siaya, Kenya
(Microbiology Resource Announcements, 2019-04-25)Here, we report the sequence of a Staphylococcus pettenkoferi clinical isolate, strain SMA0010-04 (UGA20), which contains the PC1 beta-lactamase (blaZ) gene. -
Genome Sequences of a Staphylococcus aureus Clinical Isolate, Strain SMA0034-04 (UGA22), from Siaya County Referral Hospital in Siaya, Kenya
(ASM Journals, 2019-04-25)Here, we report the genome sequences of a Staphylococcus aureus clinical isolate, strain SMA0034-04 (UGA22), which contains one chromosome and one plasmid. We also reveal that isolate SMA0034-04 (UGA22) contains loci in ... -
Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum
(BMC Med Genet., 2019-08-16)Background Severe malarial anemia (SMA) is a leading cause of malaria-related morbidity and mortality in children. The genetic factors that influence development of SMA and inefficient erythropoiesis, a central pathogenic ... -
Integrated OMICS platforms identify LAIR1 genetic variants as novel predictors of cross-sectional and longitudinal susceptibility to severe malaria and all-cause mortality in Kenyan children
(EBioMedicine, 2019-07-02)Background Severe malarial anaemia (SMA) is a leading cause of childhood mortality in holoendemic Plasmodium falciparum regions. Methods To gain an improved understanding of SMA pathogenesis, whole genome and transcriptome ... -
CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia Abstract
(Plos one, 2017-04-20)In Plasmodium falciparum holoendemic transmission regions of western Kenya, life-threatening pediatric malaria manifests primarily as severe malarial anemia (SMA, Hb≤6.0 g/dL with any density parasitemia). To determine the ... -
Changes in the frequencies of Plasmodium falciparum dhps and dhfr drug-resistant mutations in children from Western Kenya from 2005 to 2018: the rise of Pfdhps S436H
(Malaria Journal, 2020-10-22)Background Sulfadoxine-pyrimethamine (SP) is the only anti-malarial drug formulation approved for intermittent preventive treatment in pregnancy (IPTp). However, mutations in the Plasmodium falciparum dhfr (Pfdhfr) and ... -
Cyclooxygenase-2 haplotypes influence the longitudinal risk of malaria and severe malarial anemia in Kenyan children from a holoendemic transmission region.
(Journal of Human Genetics, 2019-10-29)Cyclooxygenase-2 [(COX-2) or prostaglandin endoperoxide H2 synthase-2 (PTGS-2)] induces the production of prostaglandins as part of the host-immune response to infections. Although a number of studies have demonstrated the ... -
Acceptability of a mushroom enriched composite flour and porridge among child/mother dyads (6-24months) at Nabongo dispensary, Kakamega County, Kenya
(AJOL, 2021-06-17)There has been increased emphasis on the consumption and utilization of affordable, and locally available indigenous foods in formulating food supplements due to the evidence-based nutritional and pharmacological value. ... -
Derivatization Reactions and Reagents for Gas Chromatography Analysis
(Advanced Gas Chromatography, 2012-03-21)Derivatization reactions are meant to transform an analyte for detectability in Gas Chromatography (GC) or other instrumental analytical methods. Derivatization in GC analysis can be defined as a procedural technique that ... -
Conventional Wastewater Treatment Plants as a Discharge and Source Point for Biota Exposure to Micro-pollutants
(Tylor and Francis, 2018-05-22)This chapter provides information on conventional wastewater treatment plants (WWTPs) as a discharge point, through which micro-pollutants (MPs) get into aquatic and terrestrial biota from various points of origin and ... -
Role of pore chemistry and topology in the heavy metal sorption by zeolites: From molecular simulation to machine learning.
(Science Direct, 2021-07)Zeolite frameworks can provide pores that enable selective heavy metals sorption, making these materials promising for energy-efficient heavy metals capture. In the present study, the adsorption of hazardous heavy metal ... -
Comparative Analysis of Acoustic Propagation Parameters of Natural Sounds of Anopheles gambiae s.s and Odorrana tormota Significant in Mosquito Startle
(plos one bioRxiv, 2019-08-05)Acoustics of varied frequency ranges generated naturally by animals or artificially by electronic devices have shown startle effect to insects. It has been shown that mosquitoes use the reactive near-field in antennae ... -
EMERGING TRENDS FOR ENERGY CONSUMPTION WITHIN ICT DEVICES
(International Journal of Engineering Applied Sciences and Technology, 2020-07)Abstract - The information and communication technology (ICT) is closely related to the future of global energy consumption, not only because the ICT equipment itself increasingly consumes energy, but also because it is a ... -
Current Trends In Information Technology: Which Way For Modern It Experts
(International Journal of Computer Trends & Technology, 2020-07)Information Technology is currently the enabler of most services. Advancements in technology has affected the society’s way of living both positively and negatively. Today, most of the field of human life are affected by ...
